Abstract: Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)(2)(Cl)(H2O)]center dot 5H(2)O (1), [Mn(AVT)(2)(H2O)(2)] (2), [Fe(AVT)(2)(Cl)(H2O)]center dot 9H(2)O (3), [Co(AVT)(2)(H2O)(2)]center dot 8H(2)O (4), [Ni(AVT)(2)(H2O)(2)]center dot 4H(2)O (5), [Cu(AVT)(2)(H2O)(2)] (6), [Zn(AVT)(2)]center dot 2H(2)O (7), [Pt(AVT)(2)(Cl)(2)] (8), [Au(AVT)(3)] (9), and [Pd(AVT)(Cl)(2)] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.
SPRINGER
Thermodynamics; Chemistry